Uptake of first two doses of human papillomavirus vaccine by adolescent schoolgirls in Manchester: prospective cohort study
Identifieur interne : 001D23 ( Main/Exploration ); précédent : 001D22; suivant : 001D24Uptake of first two doses of human papillomavirus vaccine by adolescent schoolgirls in Manchester: prospective cohort study
Auteurs : Loretta Brabin [Royaume-Uni] ; Stephen A. Roberts [Royaume-Uni] ; Rebecca Stretch [Royaume-Uni] ; David Baxter ; Gloria Chambers ; Henry Kitchener [Royaume-Uni] ; Rosemary MccannSource :
- BMJ [ 0959-8138 ] ; 2008-05-10.
English descriptors
- Teeft :
- Acceptability, Adolescent girls, Adolescent schoolgirls, Bivalent vaccine, Brabin, Dos, Dose vaccination schedule, First dose, First vaccine dose, Free school meals, Girls vaccinated, Greater manchester, Higher proportion, Human papillomavirus, Insufficient information, Long term safety, Main reason, National programme, Papillomavirus, Parental attitudes, Primary care trust, Primary care trusts, Programme, Public health department, Quadrivalent vaccine, Research study, Rubella vaccine, Schoolgirl, Second dose, Secondary schools, Third dose, Uptake, Vaccinated, Vaccination, Vaccination programme, Vaccine, Vaccine delivery, Vaccine doses, Vaccine uptake.
Abstract
Objective To assess the feasibility and acceptability of delivering a human papillomavirus (HPV) vaccine to adolescent girls. Design Prospective cohort study. Setting 36 secondary schools in two primary care trusts in Greater Manchester, United Kingdom. Participants 2817 schoolgirls in year 8 (12 and 13 year olds). Intervention Delivery of the bivalent vaccine at 0, 1, and 6 months over one school year. Main outcome measures Vaccine uptake for doses 1 and 2 of a three dose schedule. Results Vaccine uptake was 70.6% (1989/2817) for the first dose and 68.5% (1930/2817) for the second dose. Uptake was significantly lower in schools with a higher proportion of ethnic minority girls (P<0.001 for trend) or higher proportion of girls entitled to free school meals (P=0.029 for trend). The main reason for parents’ refusal of vaccination was insufficient information about the vaccine and its long term safety. Maintaining the vaccine schedule was challenging as 16.3% (dose 1) and 23.6% (dose 2) of girls missed their vaccination day and had to be offered alternative appointments. No serious adverse events were reported. Conclusion Delivery of the first two doses of HPV vaccine to adolescent schoolgirls is encouraging, but the success of the vaccination programme depends on high coverage for the third dose.
Url:
DOI: 10.1136/bmj.39541.534109.BE
Affiliations:
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Design Prospective cohort study. Setting 36 secondary schools in two primary care trusts in Greater Manchester, United Kingdom. Participants 2817 schoolgirls in year 8 (12 and 13 year olds). Intervention Delivery of the bivalent vaccine at 0, 1, and 6 months over one school year. Main outcome measures Vaccine uptake for doses 1 and 2 of a three dose schedule. Results Vaccine uptake was 70.6% (1989/2817) for the first dose and 68.5% (1930/2817) for the second dose. Uptake was significantly lower in schools with a higher proportion of ethnic minority girls (P<0.001 for trend) or higher proportion of girls entitled to free school meals (P=0.029 for trend). The main reason for parents’ refusal of vaccination was insufficient information about the vaccine and its long term safety. Maintaining the vaccine schedule was challenging as 16.3% (dose 1) and 23.6% (dose 2) of girls missed their vaccination day and had to be offered alternative appointments. No serious adverse events were reported. Conclusion Delivery of the first two doses of HPV vaccine to adolescent schoolgirls is encouraging, but the success of the vaccination programme depends on high coverage for the third dose.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Manchester</li></region><settlement><li>Manchester</li></settlement><orgName><li>Université de Manchester</li></orgName></list><tree><noCountry><name sortKey="Baxter, David" sort="Baxter, David" uniqKey="Baxter D" first="David" last="Baxter">David Baxter</name><name sortKey="Chambers, Gloria" sort="Chambers, Gloria" uniqKey="Chambers G" first="Gloria" last="Chambers">Gloria Chambers</name><name sortKey="Mccann, Rosemary" sort="Mccann, Rosemary" uniqKey="Mccann R" first="Rosemary" last="Mccann">Rosemary Mccann</name></noCountry><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Brabin, Loretta" sort="Brabin, Loretta" uniqKey="Brabin L" first="Loretta" last="Brabin">Loretta Brabin</name></region><name sortKey="Brabin, Loretta" sort="Brabin, Loretta" uniqKey="Brabin L" first="Loretta" last="Brabin">Loretta Brabin</name><name sortKey="Kitchener, Henry" sort="Kitchener, Henry" uniqKey="Kitchener H" first="Henry" last="Kitchener">Henry Kitchener</name><name sortKey="Roberts, Stephen A" sort="Roberts, Stephen A" uniqKey="Roberts S" first="Stephen A" last="Roberts">Stephen A. Roberts</name><name sortKey="Stretch, Rebecca" sort="Stretch, Rebecca" uniqKey="Stretch R" first="Rebecca" last="Stretch">Rebecca Stretch</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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